Throughout the years, I have attempted to heed my endocrinologists warnings about the importance of keeping my insulin below 86 F. I always carried my insulin in an insulated icepack and strived to replace it within 8 hoursbefore the ice melted. Federal government websites often end in .gov or .mil. |DxR"K]c _SR(]{Wa $a QVI !3 i@#YT `7#Hg,'/tA@aIe- '!9m "Z9 However, for highly temperature sensitive medications, a pharmacy may utilize a freezer unit without an automatic defrost cycle. Commenting is limited to medical professionals. The stability at room temperature of many pharmaceutical products labeled for storage under refrigeration is presented. This table may help to avoid unnecessary drug loss and expenditures due to improper storage temperatures. Results: Of the 189 medications listed in AHFS Drug Information 2006 for storage in a refrigerator, 89 were present in the pharmacy department's refrigerator. official website and that any information you provide is encrypted )nc0nUtb-gL9GHG/;4yaZW7-/x[4Nn~ *b Insulin Detemir (Levemir) can be stored at room temperature for 42 days. Amgen 800-772-6436 Formoterol (Foradil) Prior to dispensing, refrigerate at 36 to 46 F (2 to 8C). Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents. Prescription drug expenditures: An employer perspective. Regulation and strong quality control have ensured that temperature-sensitive medications safely reach and are safely stored by the pharmacy. Store in a refrigerator 2 to 8C (36 to 46F). Off-label information indicates stable when maintained at room temperature for up to 6 . Moderna said Thursday its Covid-19 vaccine can remain stable at temperatures found in refrigerators for three months, citing new data. It can get above 140F in a mailbox on a hot summer day. The pharmaceutical distribution chain At every point in the chain, precautions should be taken to minimise the effect of external conditions on the quality and stability of the product. 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However, because product labeling was insufficient regarding room-temperature stability and pharmacists were not routinely able to predict stability based on the physicochemical properties of the medications, the authors surveyed manufacturers about room-temperature storage of selected medications labeled for refrigeration. Stability of doripenem in vitro in representative infusion solutions and infusion bags. The objective of this study was to provide an updated table of the maximum acceptable duration that medications labeled for refrigeration may be stored at room-temperature. The .gov means its official. This information was then compiled into a table for use as a guide to control drug storage within the authors' institution. stream All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. For permissions, please e-mail: journals.permissions@oup.com. Express Scripts, for example, uses more than 20 million pounds of ice per year! drug stability; drug storage; medication errors; pharmaceutical preparations; refrigeration; safety. Learn More About our Premixes. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= When used with USB-power it keeps the pens refrigerated for unlimited time. Do not freeze and avoid direct light. Once opened, most insulin vials last up to 28 days inside or outside the fridge. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. There is, however, no greater daily challenge than making sure that my insulin is kept cool and safe. ISMP Medication Safety Alert! Acute Care Edition. Our best performing cooler can hold 2 Trulicity pens. Conclusion: Information regarding the room-temperature storage of 79 medications labeled for refrigerated storage was compiled. This document is also available on the manufacturers website for that medication. IVIG should always be infused at room temperature. Tafluoprost Zioptan YES Room temp for 28 days; keep in original foil pouch Trifluridine Viroptic YES Keep in refrigerator Multi-dose ophthalmic drops Various See labeling See manufacturer requirements for shortened stability. When flying, never pack medications in check-in luggage. The pharmacist, or pharmacy assistant, should personally hand this to the patient while verbally emphasizing the importance of the temperature issue. Please use this form to submit your questions or comments on how to make this article more useful to clinicians. The chart includes proper storage data, allowable temperature excursions and the length of time such excursions are permitted, and contact information for product manufacturers. %%EOF Update on room-temperature stability of drug products labeled for refrigerated storage. refrigerator malfunction, power outages, natural disasters, and inadvertent storage at room-temperature if the need for refrigerator is unknown. Store at 20-25C (this refers to the vial prior to compounding). Issues relating to temperature-sensitive medications are seriousand they are affecting more and more people. No a. a All unused Norditropin products must be refrigerated (36F to 46F) prior to first use. I consider myself fortunate as I have been able to maintain good glycemic control over the years. hb```M~ cc`aq@a/O(C" H82t*\S, j2UFMzCD(ztZh PZa0J i`1@ Bethesda, MD 20894, Web Policies It cannot be assumed that the patient will look it up. Sometimes the specifications are a bit more complicated. 8. ugD A user-restricted, peer-to-peer discussion board that allows open discussion in near-real time. endstream endobj 40 0 obj <>>> endobj 41 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[0.0 0.0 585.0 783.0]/Type/Page>> endobj 42 0 obj <>stream Succinylcholine is stable for 30 days at room temperature. Like . Temperature ranges for all prescription medications are readily available from various sources, including section 16 of the Full Prescribing Information document, which usually accompanies each prescription. Am J Health Syst Pharm. Store at room temperature 68 to 77F (20 to 25C). Subanesthetic Ketamine for Acute Pain in Critically Ill Patients, FDA Grants Accelerated Approval for Controversial Novel Alzheimers Drug, Analgesia and Sedation Strategies in COVID-19 Patients, New Guidelines Shore Up Smart Infusion Pump Safety. They pool it into a bag in a sterilized room & then they will refrigerate for the next day & then take it out in the morning while they are packaging up all the supplies . For example, diazepam loses 25% of its potency when stored over 98F. The loss of efficacy can result in many issues compromising the health of the patient. Would you like email updates of new search results? 2007;64(16):1711-1715. To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. Accessibility You will receive email when new content is published. Off-label information indicates stable when maintained at room temperature for up to 6 months. Am J Health Syst Pharm. We are now the United States distributor of the FRIO evaporative medication cooling case. Know the safe temperature storage range for each of your medications. % Careers. Store in a refrigerator, 2 to 8C (36 to 46F). There are also conflicts with advertisements purporting that some types of insulin do not need a coolerwithout a clear reminder that the medication still needs to be kept at or below 86F. Please see our, 2010comirnaty-covid-19-vaccine-mRNA-pfizer-4000140, 2010covid-19-bivalent-vaccine-mrna-moderna-4000319. and transmitted securely. Stability studies to support product handling during preparation and transport The manufacturer must document temperature influence during handling of intermediates, bulk products, packed products until they are stored in the defined final storage conditions. Once reconstituted, the manufacturer recommends use within 8 hours. Am J Health Syst Pharm. Liquid vaccines containing an aluminum adjuvant permanently lose potency when exposed to freezing temperatures. American Journal of Health-System Pharmacy, Regranex topical gel (Ortho-McNeil-Janssen), Diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine combined, Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed, Erythromycin ethylsuccinate oral suspension, Enbrel (Immunex Corporation [Amgen and Wyeth Pharmaceuticals]), Repeated periods of exposure for a combined maximal duration of 6 days, Filgrastim vials and Singleject prefilled syringes, Insulin glargine (rDNA origin) vial or cartridge, Lantus vial or cartridge (Sanofi-Aventis), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) pen fill cartridge, Novolog Mix 70/30 pen fill cartridge (Novo Nordisk), 70% insulin aspart protamine suspension and 30% insulin as part injection (rDNA origin) vial, Lente human insulin (rDNA origin) zinc suspension, NPH, human insulin isophane suspension (rDNA origin), Regular human insulin injection (rDNA origin), Humulin Ultralente human insulin (rDNA origin) extended zinc suspension, Neomycin sulfate-polymixin B sulfate solution for irrigation, Neosporin G.U. 2022 Jun 7;79(12):932-933. doi: 10.1093/ajhp/zxac060. Conclusion: However, for storage beyond 28 days (some insulin brands are for up to 42 days), the insulin must be refrigerated. Always keep your medication in your carry-on bag. Victor Cohen,1,2 Samantha P. Jellinek,1 Leftherios Teperikidis,1 Elliot Berkovits,1 William M. Goldman 1,2 1Maimonides Medical Center, Brooklyn, NY 2Long Island University, Brooklyn, NY. Store in refrigerator at 2 to 8 C. Another large study tested the stability of Keflex (cephalexin) suspension in polypropylene oral syringes, stored at various temperatures (-4, 39.2, 77, 104 . Enter your email address to receive important announcements and updates through the ASPR TRACIE Listserv. It is also important that the pharmacist emphasize the importance of keeping the medication within that temperature range at all times. 2021 Jul 23:zxab297. And most medications must be stored at a controlled room temperature of around 68 to 77 degrees F once you get them. Adrenaline hydrochloride and methylergonovine maleate remained stable for several months Improper storage of these suspensions might not only affect stability, but also the flavor or pourability of the product. U.S. Department of Health & Human Services, Review Select Technical Assistance Responses. Protect from light. For mail order medications, be sure the medication is not left in the mailbox for more than a day. The table is intended to be used as a guide when temperature excursion occurs, e.g. This site needs JavaScript to work properly. Refrigeration of medications is often required to maintain medication stability and increase a drug's shelf life. aF} s^,jS5#8B~jez$'VhaFz{pO~9gOFG1r("S9Q#E9",}bnXo n?uYjXSG3g,/gZwf{i*)a$U1zE>GEP.NPP Store lyophilized Activase at controlled room temperature not to exceed 30C (86F). Of the 705 products or formulations approved by FDA during the predefined time period, 246 were identified as requiring storage at temperatures below room temperature. According to the product labels from all three U.S. insulin manufacturers, it is recommended that insulin be stored in a refrigerator at approximately 36F to 46F. s hX There are no data on sterility after dilution. If used with freeze packs (no electricity required), it keeps the pens refrigerated for up to 33 hours and at room temperature for 52 hours (when outside temperature is at 86F / 30C). Augmentin Suspension - degrades at room temperature and develops a brown discoloration. H|TMo0+>*8`>WrhJRS5[MF Room Temperature. The site is secure. We conducted the survey to learn more about what resources pharmacists rely on to guide drug storage, stability, and beyond use dating. endobj Recommendations based on a review of these errors suggested displaying a table on the outside of the refrigerator door listing common refrigerated items for that particular unit. If insulin is cloudy, it is compromised. It is recommended that, if not used immediately after preparation, diluted solutions should be refrigerated and used within 48 hours. When stored at room temperature or in the emergency physician transport vehicle, lorazepam became unstable within weeks, whereas succinylcholine chloride and cisatracurium besylate became unstable within months. The included tables may increase patient safety and decrease medication loss or related expenditures. Keep from freezing. Frozen antibiotics thawed in the refrigerator and extemporaneously compounded medications were excluded. Purpose: The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency. If you need to carry your medication with you (traveling or just during the length of the day), use a medication cooler. Vials may be held up to 12 months upon removal from refrigeration to room temperature storage conditions (20C to 25C [68F to 77F], USP Controlled Room Temperature), anytime within the labeled shelf life. During this time, my blood sugars were out of control. Do not place medications in an area of sunlight. The effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. 2007 Aug 15;64(16):1711-5. doi: 10.2146/ajhp060262. Some arent aware of the temperature constraints at all. N7 qlEv:F}Py,:+YJ?{$`EQ5m&/]$feCEUaVTVGuB+4k[G Pharma-Mon by AKCP. Click the topic below to receive emails when new articles are available. Budgeting in the post-COVID era: Be in the room where it happens. For example, diazepam loses 25% of its potency when stored over 98F. These same medications also allow for temporary excursion periods ranging as low as 59F and as high as 86F. after 24 hours of storage at room- temperature, when stored in a cool place (8-15 C), and when stored at room-temperature (15-30 C). Another study by Tu et al. Find lorazepam injection, USP VIAL medical information: Search If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents. 8 Telephone surveys and follow-up inquiries of the products' manufacturers were conducted when information about room-temperature storage was not available in the prescribing information. Lorazepam loses 75% of its potency at that temperature. Stable at room temperature for up to 24 hours. $t@I|Tf:0UzX\fZyz1-7Eu3Z k\?.uV;hO%-gU;ZX0c}]tY4?vgQ^JYVvI-de5[RFW: d|5[VRVZ;/cWJS\,U*b3RP6^AParSJ\e+Se%XjBDs2(#NyCexk+41VP>Pi%*D Z*8;\/{w7_>.38'$je8/kPo?|Y05)u:P#q@e/u6yEY\~6P41KA@''@wl>$X#n~1z2@m!oCnN% ,q=xVX^eZYAja=9'kX f8l6/a;s+"8f.MY,Wbm}a~bmP_k1g-SOZXS Originally prepared by: Brandon Flohr Pharm.D. Guidelines CERVIDIL must be kept frozen until use and is stable when stored in a freezer for a period of 3 years There is no need for previous warming of the product Insert immediately after removal from its foil package CERVIDIL does not require sterile conditions CERVIDIL must not be used without its retrieval system Cohen V, Jellinek SP, Teperikidis L, Berkovits E, Goldman WM. I am one of millions of people dependent on insulin. These same medications also allow for temporary "excursion" periods ranging as low as 59F and as high as 86F. Reconstituted Vial/Powder: Notes: P-Insert Updated: . Famotidine in D5W and in 0.9% Sodium Chloride: Physically compatible with no potency loss in 14 days at 4C. Many sterilants and disinfectants must be stored below 30 C (86 F). HHS Vulnerability Disclosure, Help Newer evidence suggests that 1 mg/mL solutions may be stored at room temperature for 3 days or . endstream endobj 156 0 obj <>stream Am J Health Syst Pharm. Disclaimer. When driving, keep your medication in the climate-controlled interior of the car, not the trunk. Bethesda, MD 20894, Web Policies "F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VKYdE"EI2EBGt4MzNr!YK ?%_&#(0J:EAiQ(()WT6U@P+!~mDe!hh/']B/?a0nhF!X8kc&5S6lIa2cKMA!E#dV(kel }}Cq9 A medication fridge should provide a stable temperature of between 36 and 46 degrees F. A good rule of thumb is to set your medication refrigerator at the middle point between the minimum and maximum storage temperature to allow for a proper storage temperature even with small fluctuations due to the door being opened during the day. Methods: Product found to be stable after a freeze-thaw cycle Paragon Bio Teck, Inc 503-465-3802 Crotalidae Immune Fab (CroFab) Unreconstituted vials remain stable if exposed to 10C to +2C during 1 continuous excursion of 12 hr BTG International, Inc 877-377-3784 Digoxin Immune Fab (DigiFab) Despite my usual intake of carb units and dosage of insulin, my blood glucose levels sometimes skyrocketed. An official website of the United States government. degredation in the same time period at room temperature of 20C. The diluted solution is stable for 24 hours at room temperature. During a 12-month period ending in June 2021, the prescribing information and published monographs from multiple pharmacy compendia were reviewed for all medications and biologic products approved by the US Food and Drug Administration (FDA) for human use since January 2000. In our business, we frequently receive calls from patients who are completely unaware of the upper temperature limit for their medicationsand this is the select segment of the population that has the presence of mind to inquire about a cooler. Q$C#vEWYFmW>{OYYj pGeKZ>]f0/.I/L@rIw:SkhfH *- vlPe:.qA[@:\gH2y%/c,\TjpL!H=8&Y4{(|!zsGrWhZIsJrb(D9S;1q04)M9)kKHy@4b?m/*yodpBMLM%(z*AFJF;KZ'unvF5pk8Z]1m:m4J5Bmw` u You've successfully added to your alerts. Succinylcholine is stable for 30 days at room . Unable to load your collection due to an error, Unable to load your delegates due to an error. It is also beneficial to patients if the pharmacy can provide practical tips as to how to keep their medication cool. This is extremely important information, as the full spectrum of mistakes is made by patients. Z8Q]{lCR)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O Electric medication storage boxes are available and for long expeditions are a reasonable solution. If approved, the option to store at -25C to -15C (-13F to 5F) for two weeks would be in addition to this five-day option to store at standard refrigerator temperature. Am J Health Syst Pharm. There are ice pack coolers which will keep your medication cool for up to 8 hours (between activations) and evaporative coolers, which will keep your medication cool for 2 to 3 days (between activations). %%EOF %PDF-1.4 % Am J Health Syst Pharm. Remember, ENBREL can be kept at room temperature between 68F to 77F for up to 30 days, which means you may be able to travel for up to 4 weeks with ENBREL without needing to keep it refrigerated. 1. Any break in cold-chain storage can potentially affect the safety and efficacy of a medication that requires special temperature requirements. Clipboard, Search History, and several other advanced features are temporarily unavailable. Online ahead of print. However, insulin can be kept at room temperature, meaning not in the refrigerator for approximately 28-30 days. Please enable it to take advantage of the complete set of features! Of the 189 medications listed in AHFS Drug Information 2006 for storage in a . It is observed that many drug products labeled for refrigerated storage are stable at room temperature for extended periods. This website also contains material copyrighted by 3rd parties. With over 30 years experience in providing professional sensor solutions our pharma-mon line of products are tailored specifically for the needs of the pharmaceutical industry. The lows, the highs, the counting carbs, timing of meals, variability caused by exercise—are all challenges that I face every day. Copyright 2000 - 2023 Jobson Medical Information LLC unless otherwise noted. By first becoming as knowledgeable as possible on this important subject and then passing on that knowledge to the patient, the trusted pharmacist is in a unique position to provide this important service to those that he or she serves. Results: Since six manufacturers were unable to provide information for 10 medications, only 79 medications were included in the review. hb```rNaf`f`s\``0`!ck[AT&QX0Y.!v@kDgi~0ci [1$Q'8_F254X}! Norepinephrine, 4 mcg/mL or 16 mcg/mL, in NS or D5W, was stable for up to 7 days at room temperature and ambient light. HTn@y\W)iV>E} \"Pn~}g%%eyY9gf-r p CEc40T/||| With more and more people dependent on temperature- sensitive medications and with summer temperatures seeming to be higher every year, this is a growing issue that needs immediate attention. The U.S. Pharmacopeia's definition of room temperature (20-25 degrees C [68-77 degrees F]) was used for this review. Uses for Rocuronium Skeletal Muscle Relaxation 2007;64(16):1711-1715. kk._Q??u!uY6[[E[j! It is with the patient, because of lack of awareness and adherence, where there is the greatest opportunity for medications to lose their efficacy due to exposure to heat. The https:// ensures that you are connecting to the stream Reproduction in whole or in part without permission is prohibited. Allergen immunotherapy: a practice parameter, second update. And, the same guidelines quite clearly state that "allergen immunotherapy extract should be stored at 4 degrees centigrade to reduce the rate of potency loss." These guidelines review studies looking at the stability of extract. The presence of CCP antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of rheumatoid arthritis (RA). Federal government websites often end in .gov or .mil. The following AANA Journal course discusses anesthesia-related medications that require refrigeration and how long potency and safety is maintained out of the refrigerator and pro& _&V4.A#j7B WG 3 CJ ] q E '}e Please see our. Dan Katzki is the chief operating officer of ReadyCare, the national distributor of the FRIO medication cooling case (www.FRIOCase.com). Bortezomib is one example. Insulin is only 1 of scores of temperature-sensitive medications on which people depend. 1989;23(4):197-207. doi: 10.1007/BF00451642. ) Refrigerate at 36 to 46 F (2 to 8C). The data were obtained through a survey of manufacturers. Pharmacists can improve patient adherence by providing education on the importance of keeping medications within proper temperature range. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Am J Health Syst Pharm. It is vital that the pharmacist educate each patient on the temperature specifications of their medication. The site is secure. All rights reserved. Pharmacist awareness, coupled with proper patient education and counseling by the pharmaceutical staff, can all but eliminate the consequences of this issue and improve the quality of life for all patients served. It was only after I went to the pharmacy, spent a great deal of money, and replaced the insulin (insulin, beyond the prescribed dose, is not covered by insurance) that I was able to bring things back into control. As it may take time to go over this during a consultation, I recommend that the pharmacy prepare a Helpful Tips list. It is important to note that there can still be a decrease in efficacy even if there is not a visible difference. Unopened insulin vials can be stored in the fridge until their expiration date, and outside the fridge for 28 days. Fortunately, the supply chain for temperature-sensitive medications in the UnitedStates has proved to be safe. National Library of Medicine After 0, 1, 3, 7 and 14 days of storage, the stability of the emulsions was examined via visual inspection and was assessed by droplet size and zeta potential. Please confirm that you would like to log out of Medscape. The pharmacist should know the recommended safe storage temperatures for every medication dispensed. An official website of the United States government. And it is with the pharmaceutical professional who dispenses the medication where there is the greatest opportunity to minimize this risk. When parked, do not keep your medication inside a hot car; it can also get above 140F inside a parked car. Refrigerated and/or frozen storage of medications is typically performed to maintain medication stability for longer durations and increase the product shelf life. x- [ 0}y)7ta>jT7@t`q2&6ZL?_yxg)zLU*uSkSeO4?c. R -25 S>Vd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L` "AYA+Cb(R, *T2B- Storage Temperature. Please enter a Recipient Address and/or check the Send me a copy checkbox. 5 0 obj The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Methods: During May and June of 2006, the prescribing information for medications labeled for refrigeration as obtained from the supplier were reviewed for data addressing room-temperature storage. The list should include the following tips: 1. Although manufacturers recommend storing your insulin in the refrigerator, injecting cold insulin can sometimes make the injection more painful. Provides access to Technical Assistance Specialists for one-on-one support. N')].uJr Purpose: Data regarding the recommended maximum duration that refrigerated medications available in hospital pharmacies may be stored safely at room temperature were collected and compiled in a tabular format. Of the top 10 medications prescribed, all have upper temperature limits. American Society of Health-System Pharmacists 2022. The https:// ensures that you are connecting to the FOIA Store at room temperature 68 to 77F (20 to 25C). 39 0 obj <> endobj To avoid this, many providers suggest storing the bottle of insulin you are using at room temperature. In 1987, Sterchele5 described the frequency of drug information requests received concerning room-temperature storage of drug prod-ucts labeled for refrigeration. No a. FlexPro 30 mg/3 mL. Despite my best efforts, I apparently did not always replace the ice in time. The Disaster Available Supplies in Hospitals (DASH) Tool, ASPR's 2019 Novel Coronavirus Disease Page. My insulin looked the same, was not warm when I inspected it, and was obviously still workingat least to some degree. Cite this: Room-temperature Storage of Medications Labeled for Refrigeration-Medscape-Aug01,2007. government site. This site needs JavaScript to work properly. A&k]h/+ulm.d!*/XHvPr]SjTHc%t ?($uL Db~4;22bt`gE[6Pi*8G:#k:V`BQS=X9R2N$ARz ]x~#RVY2ZdVX lr+baz|To+-$`>*>c 7o&. %PDF-1.3 Find BICILLIN L-A medical information: . If you log out, you will be required to enter your username and password the next time you visit. A unit that contains a freezer compartment within the refrigerator space, such as a dorm-style refrigerator, is not permitted. This information was limited by the fact that it was collected outside of the United States and published in the Spanish medical literature. (?6"9}^/*mss}Rg+~@ Also, remember that once ENBREL reaches room temperature, you cannot put it back in the fridge. Temperatures above and beyond this range can have a significant effect on each medication. AKCP is the worlds leader in network enabled sensors. I have type 1 diabetes mellitusand have had it since 1986. Classifying investigational medications for USP <800>: Strategies and considerations. The time taken for the original concentration of potassium clavulanate to drop to 90% of its value at room temperature of 20C is 2 days (Mehta et al., 2008). 6. Diluted famotidine injection has been shown to be physically and chemically stable for 7 days at room temperature. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin L-A and other antibacterial drugs, Bicillin L-A should be used only to .